MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile
Identifieur interne : 000912 ( Main/Exploration ); précédent : 000911; suivant : 000913MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile
Auteurs : Waleed H. Mahallawi [Arabie saoudite] ; Omar F. Khabour [Arabie saoudite, Jordanie] ; Qibo Zhang [Royaume-Uni] ; Hatim M. Makhdoum [Arabie saoudite] ; Bandar A. Suliman [Arabie saoudite]Source :
- Cytokine [ 1043-4666 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Cellules Th17 (métabolisme), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Cytokines (), Cytokines (métabolisme), Cytokines (sang), Humains, Infections à coronavirus (immunologie), Infections à coronavirus (sang), Infections à coronavirus (virologie), Interférons (métabolisme), Interférons (sang), Jeune adulte, Lymphocytes auxiliaires Th1 (métabolisme), Mâle, Structure secondaire des protéines.
- MESH :
- immunologie : Infections à coronavirus.
- métabolisme : Cellules Th17, Cytokines, Interférons, Lymphocytes auxiliaires Th1.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- sang : Cytokines, Infections à coronavirus, Interférons.
- virologie : Infections à coronavirus.
- Adulte, Adulte d'âge moyen, Cytokines, Humains, Jeune adulte, Mâle, Structure secondaire des protéines.
English descriptors
- KwdEn :
- Adult, Coronavirus Infections (blood), Coronavirus Infections (immunology), Coronavirus Infections (virology), Cytokines (blood), Cytokines (chemistry), Cytokines (metabolism), Humans, Interferons (blood), Interferons (metabolism), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (physiology), Protein Structure, Secondary, Th1 Cells (metabolism), Th17 Cells (metabolism), Young Adult.
- MESH :
- chemical , blood : Cytokines, Interferons.
- blood : Coronavirus Infections.
- chemical , chemistry : Cytokines.
- immunology : Coronavirus Infections.
- chemical , metabolism : Cytokines, Interferons, Th1 Cells, Th17 Cells.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Adult, Humans, Male, Middle Aged, Protein Structure, Secondary, Young Adult.
Abstract
MERS is caused by a single-stranded RNA virus named MERS-corona virus. Infection with MERS-CoV elicits a type-I and type-II interferon response. MERS-CoV infected patients show a prominent Th1 and Th17 cytokine profile. MERS-CoV infection induces the expression of IL-10.
Url:
DOI: 10.1016/j.cyto.2018.01.025
PubMed: 29414327
PubMed Central: 7129230
Affiliations:
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Le document en format XML
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Khabour</name><affiliation wicri:level="1"><nlm:aff id="af005">Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Madinah</wicri:regionArea><wicri:noRegion>Madinah</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af020">Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan</nlm:aff><country xml:lang="fr">Jordanie</country><wicri:regionArea>Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid</wicri:regionArea><wicri:noRegion>Irbid</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Qibo" sort="Zhang, Qibo" uniqKey="Zhang Q" first="Qibo" last="Zhang">Qibo Zhang</name><affiliation wicri:level="1"><nlm:aff id="af010">Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool</wicri:regionArea><wicri:noRegion>University of Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Makhdoum, Hatim M" sort="Makhdoum, Hatim M" uniqKey="Makhdoum H" first="Hatim M." last="Makhdoum">Hatim M. 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(physiologie)</term><term>Cytokines ()</term><term>Cytokines (métabolisme)</term><term>Cytokines (sang)</term><term>Humains</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (sang)</term><term>Infections à coronavirus (virologie)</term><term>Interférons (métabolisme)</term><term>Interférons (sang)</term><term>Jeune adulte</term><term>Lymphocytes auxiliaires Th1 (métabolisme)</term><term>Mâle</term><term>Structure secondaire des protéines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term><term>Interferons</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" 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xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Protein Structure, Secondary</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cytokines</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Structure secondaire des protéines</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label><p id="p0005">MERS is caused by a single-stranded RNA virus named MERS-corona virus.</p></list-item><list-item id="o0010"><label>•</label><p id="p0010">Infection with MERS-CoV elicits a type-I and type-II interferon response.</p></list-item><list-item id="o0015"><label>•</label><p id="p0015">MERS-CoV infected patients show a prominent Th1 and Th17 cytokine profile.</p></list-item><list-item id="o0020"><label>•</label><p id="p0020">MERS-CoV infection induces the expression of IL-10.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mackay, I M" uniqKey="Mackay I">I.M. Mackay</name></author><author><name sortKey="Arden, K E" uniqKey="Arden K">K.E. Arden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, C" uniqKey="Thomas C">C. Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almaghrabi, R S" uniqKey="Almaghrabi R">R.S. Almaghrabi</name></author><author><name sortKey="Omrani, A S" uniqKey="Omrani A">A.S. Omrani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, W J" uniqKey="Liu W">W.J. Liu</name></author><author><name sortKey="Zhao, M" uniqKey="Zhao M">M. Zhao</name></author><author><name sortKey="Liu, K" uniqKey="Liu K">K. Liu</name></author><author><name sortKey="Xu, K" uniqKey="Xu K">K. Xu</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G. Wong</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W. 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Pitha</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Jordanie</li><li>Royaume-Uni</li></country></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Mahallawi, Waleed H" sort="Mahallawi, Waleed H" uniqKey="Mahallawi W" first="Waleed H." last="Mahallawi">Waleed H. Mahallawi</name></noRegion><name sortKey="Khabour, Omar F" sort="Khabour, Omar F" uniqKey="Khabour O" first="Omar F." last="Khabour">Omar F. Khabour</name><name sortKey="Makhdoum, Hatim M" sort="Makhdoum, Hatim M" uniqKey="Makhdoum H" first="Hatim M." last="Makhdoum">Hatim M. Makhdoum</name><name sortKey="Suliman, Bandar A" sort="Suliman, Bandar A" uniqKey="Suliman B" first="Bandar A." last="Suliman">Bandar A. Suliman</name><name sortKey="Suliman, Bandar A" sort="Suliman, Bandar A" uniqKey="Suliman B" first="Bandar A." last="Suliman">Bandar A. Suliman</name></country><country name="Jordanie"><noRegion><name sortKey="Khabour, Omar F" sort="Khabour, Omar F" uniqKey="Khabour O" first="Omar F." last="Khabour">Omar F. Khabour</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Zhang, Qibo" sort="Zhang, Qibo" uniqKey="Zhang Q" first="Qibo" last="Zhang">Qibo Zhang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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